Entry Detail

General Information

Database ID: LDA0015455
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LOXL1-AS1
Full Name:LOXL1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:15
Strand:-
Coordinate:
Start Site(bp):73917468End Site(bp):73928248
External Links:
Ensembl ID:ENSG00000261801
Ensembl Transcript ID:N/A
Entrez Gene:100287616.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:44   
More Information
Causal Disease Number:42
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3594D002822
Disease Name:choriocarcinomaChoriocarcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A placenta cancer that has_material_basis_in trophoblastic cells.A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
Alias:ChorioepitheliomaChoriocarcinoma//Choriocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
PCA3  (Score: 0.731059)
PCA3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33278425
Disease Name:choriocarcinoma
Sample:human choriocarcinoma cells
Dysfunction Pattern:Regulation(miR-515-5p )
Validated Method:Western Blot//Transfection//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Description:Our results showed that human placental trophoblast cells had higher level of LOXL1-AS1 in comparison to human choriocarcinoma cells, however, human placental trophoblast cells had lower level of miR-515-5p. In addition, the expression of CyclinD1, MMP2, MMP9 were significantly decreased in JeG-3 cell lines. We observed lower cell survival rate and lower cell migration number in JeG-3 cell lines. Our results demonstrated that LOXL1-AS1 could target miR-515-5p, and subsequently reverse the inhibitory effect of LOXL1-AS1 on proliferation and migration in JEG-3 cells. Also, lower expressions of p-p65 and p-IкBα in JeG-3 cells showed that miR-515-5p could reversed the inhibitory effect of LOXL1-AS1 on NF-κB signaling pathway.
Causality:No
Causal Description:
Clinical-realted Application: