Entry Detail


General Information

Database ID: LDA0015732
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NCK1-DT
Full Name:NCK1 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:NCK1-AS1|SLC35G2-AS1
Chromosome:3
Strand:-
Coordinate:
Start Site(bp):136841976End Site(bp):136862063
External Links:
Ensembl ID:ENSG00000239213
Ensembl Transcript ID:N/A
Entrez Gene:101927597.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D011470
Disease Name:Prostatic Hyperplasia
Category:MeSH
Type:Urogenital Diseases
Define:Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.
Alias:Prostatic Hyperplasia//Hyperplasia, Prostatic//Adenoma, Prostatic//Adenomas, Prostatic//Prostatic Adenomas//Prostatic Adenoma//Benign Prostatic Hyperplasia//Benign Prostatic Hyperplasias//Hyperplasia, Benign Prostatic//Hyperplasias, Benign Prostatic//Prostatic Hyperplasias, Benign//Prostatic Hypertrophy, Benign//Benign Prostatic Hypertrophy//Hypertrophy, Benign Prostatic//Prostatic Hyperplasia, Benign//Prostatic Hypertrophy//Hypertrophies, Prostatic//Hypertrophy, Prostatic//Prostatic Hypertrophies

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31807161
Disease Name:Prostatic Hyperplasia
Sample:blood
Dysfunction Pattern:Interaction[TGF-β1]
Validated Method:qRT-PCR
Description:It was revealed in the present study that plasma NCK1-AS1 was upregulated in patients with PC when compared with patients with benign prostatic hyperplasia (BPH) and healthy controls. Overexpression of NCK1-AS1 led to significantly upregulated transforming growth factor (TGF)-β1, while TGF-β1 overexpression failed to significantly affect NCK1-AS1 in PC cells. NCK1-AS1 overexpression led to promoted migration and invasion. TGF-β inhibitor played an opposite role and attenuated the effects of NCK1-AS1 overexpression. Therefore, NCK1-AS1 may upregulate TGF-β1 to promote PC.
Causality:No
Causal Description:
Clinical-realted Application: