Entry Detail

General Information

Database ID: LDA0015756
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050855
Disease Name:renal fibrosis
Category:Disease Ontology
Type:Urogenital Diseases
Define:A kidney disease that is characterized by progressive detrimental connective tissue deposition of the kidney parenchyma leading to deterioration of renal function.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
Gas5  (Score: 0.731059)
lnc-CHAF1B-3  (Score: 0.731059)
hsa_circ_30032  (Score: 0.731059)
circPTPN14  (Score: 0.731059)
circPlekha7  (Score: 0.731059)
PVT1  (Score: 0.731059)
Gas5  (Score: 0.731059)
lnc-CHAF1B-3  (Score: 0.731059)
hsa_circ_30032  (Score: 0.731059)
circPTPN14  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//ELISA//IHC
Weak Evidence:

 

Reference

[1] PubMed ID:36440854
Disease Name:renal fibrosis
Sample:renal tissues
Dysfunction Pattern:Interaction(miR-31)
Validated Method:Western Blot//qRT-PCR//FISH//RIP//Luciferase Report Assay//H&E Staining//ELISA//IHC
Description:We showed that NEAT1 was highly expressed, whereas miR-31 was decreased in renal fibrosis. NEAT1 was found to directly bind miR-31 to positively regulate RhoA expression. Furthermore, NEAT1 silencing inhibited renal fibrosis and inflammation and suppressed the RhoA/ROCK1 signaling pathway. However, knockdown of miR-31 could reverse these effects. NEAT1 silencing or overexpression of miR-31 alleviated renal fibrosis in vivo.
Causality:No
Causal Description:
Clinical-realted Application: