Entry Detail

General Information

Database ID: LDA0015758
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3770D011658
Disease Name:pulmonary fibrosisPulmonary Fibrosis
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation.A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Alias:Fibrosis of lungPulmonary Fibrosis//Fibrosis, Pulmonary//Pulmonary Fibroses//Fibroses, Pulmonary//Alveolitis, Fibrosing//Alveolitides, Fibrosing//Fibrosing Alveolitides//Fibrosing Alveolitis//Idiopathic Diffuse Interstitial Pulmonary Fibrosis

 

Disease Association Statistics

Total Associated ncRNA Number:64   
More Information
Causal ncRNA Number:16
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
DACH1  (Score: 0.731059)
Rmrp  (Score: 0.731059)
circANKRD42  (Score: 0.731059)
Zfas1  (Score: 0.731059)
hsa_circ_0026344  (Score: 0.731059)
hsa_circ_0044226  (Score: 0.731059)
MIR99AHG  (Score: 0.731059)
H19  (Score: 0.731059)
DACH1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:32894569
Disease Name:Pulmonary Fibrosis
Sample:PF tissues and cells
Dysfunction Pattern:regulation[miR-9-5p and TGF-β signaling pathway]
Validated Method:qRT-PCR//Luciferase Report Assay//Western Blot
Description:We observed that NEAT1 was significantly upregulated while miR-9-5p was downregulated in PF tissues and TGF-β1-induced cells. Taken together, our findings showed that NEAT1 knockdown attenuated PF via the regulatory of miR-9-5p and TGF-β signaling to repress EMT and might provide new therapeutic targets for PF patients.
Causality:No
Causal Description:
Clinical-realted Application: