Entry Detail

General Information

Database ID: LDA0015760
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8947D003930
Disease Name:diabetic retinopathyDiabetic Retinopathy
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Alias:Retinal abnormality - diabetes-relatedDiabetic Retinopathy//Diabetic Retinopathies//Retinopathies, Diabetic//Retinopathy, Diabetic

 

Disease Association Statistics

Total Associated ncRNA Number:34   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
ZNF503-AS1  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
FLG-AS1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
LINC00673  (Score: 0.731059)
SNHG16  (Score: 0.731059)
VEAL2  (Score: 0.731059)
MAP4K2  (Score: 0.731059)
TDRG1  (Score: 0.731059)
SNHG7  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:32356340
Disease Name:Diabetic Retinopathy
Sample:patients with DR
Dysfunction Pattern:regulation[TGF-β1 and VEGF signaling pathways]
Validated Method:qRT-PCR
Description:Here, we found the NEAT1 level was significantly elevated in patients with DR, in the retina of diabetic rats and mice. Hence, we concluded NEAT1 might contribute to the development of DR through activating TGF-β1 and VEGF.
Causality:No
Causal Description:
Clinical-realted Application: