Entry Detail


General Information

Database ID: LDA0015763
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NEAT1
Full Name:nuclear paraspeckle assembly transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00084|NCRNA00084|TP53LC15|TncRNA|VINC
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65422798End Site(bp):65445540
External Links:
Ensembl ID:ENSG00000245532
Ensembl Transcript ID:N/A
Entrez Gene:283131.0
NONCODE ID:N/A
RefSeq Accession:NR_131012.1

 

ncRNA Association Statistics

Total Associated Disease Number:190   
More Information
Causal Disease Number:146
Network:
Top Causal Diseases:
Parkinson Disease  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Non-alcoholic Fatty Liver Disease  (Score: 1)
Parkinson Disease  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007037
Disease Name:Hypothyroidism
Category:MeSH
Type:Endocrine System Diseases
Define:A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
Alias:Hypothyroidism//Hypothyroidisms//Primary Hypothyroidism//Hypothyroidism, Primary//Primary Hypothyroidisms//Thyroid-Stimulating Hormone Deficiency//Deficiency, Thyroid-Stimulating Hormone//Hormone Deficiency, Thyroid-Stimulating//Thyroid Stimulating Hormone Deficiency//Thyroid-Stimulating Hormone Deficiencies//TSH Deficiency//Deficiency, TSH//TSH Deficiencies//Secondary Hypothyroidism//Hypothyroidism, Secondary//Secondary Hypothyroidisms//Central Hypothyroidism//Central Hypothyroidisms//Hypothyroidism, Central

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33677813
Disease Name:Hypothyroidism
Sample:
Dysfunction Pattern:Interaction(miR-126/TRAF7 pathway)
Validated Method:In Vivo Experiment//Western Blot//Transfection//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Cell Proliferation Assay
Description:Furthermore, lncRNA NEAT1 was upregulated upon TSH treatment and could function as a ceRNA and bind to miR-126, thus, modulating its expression level and vascular function. Finally, the NEAT1/miR-126/TRAF7 axis functions in response to TSH and regulates endothelial functions in SCH in vitro and in vivo.
Causality:No
Causal Description:
Clinical-realted Application: