Entry Detail


General Information

Database ID: LDA0015909
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NKILA
Full Name:NF-kappaB interacting lncRNA
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):57710183End Site(bp):57712780
External Links:
Ensembl ID:ENSG00000278709
Ensembl Transcript ID:N/A
Entrez Gene:105416157.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:44   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Retinoblastoma  (Score: 0.985791)
Retinoblastoma  (Score: 0.985791)
Osteosarcoma  (Score: 0.731059)
cervical squamous cell carcinoma  (Score: 0.731059)
Diabetic Cardiomyopathies  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Cholangiocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7147D013167
Disease Name:ankylosing spondylitisSpondylitis, Ankylosing
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
Alias:Bekhterev syndrome//Bekhterev's disease//Marie-Strumpell diseaseSpondylitis, Ankylosing//Bechterew's Disease//Bechterews Disease//Marie-Struempell Disease//Marie Struempell Disease//Spondylarthritis Ankylopoietica//Spondyloarthritis Ankylopoietica//Ankylosing Spondylitis//Ankylosing Spondylarthritis//Ankylosing Spondylarthritides//Spondylarthritides, Ankylosing//Spondylarthritis, Ankylosing//Ankylosing Spondyloarthritis//Ankylosing Spondyloarthritides//Spondyloarthritides, Ankylosing//Spondyloarthritis, Ankylosing//Spondylitis Ankylopoietica//Bechterew Disease//Rheumatoid Spondylitis//Spondylitis, Rheumatoid

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
hsa_circ_0056558  (Score: 0.731059)
hsa_circ_0003307  (Score: 0.731059)
hsa_circ_0056558  (Score: 0.731059)
hsa_circ_0003307  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:31173579
Disease Name:Spondylitis, Ankylosing
Sample:blood
Dysfunction Pattern:Interaction[TGF-β1]
Validated Method:qRT-PCR//ELISA
Description:In the present study we found that plasma lncRNA NKILA was expressed at higher levels in active ankylosing spondylitis patients than in healthy controls.Plasma levels of TGF-ß1 were also higher in active ankylosing spondylitis patients than in healthy controls. Levels of plasma lncRNA NKILA and TGF-ß1 were significantly and positively correlated in ankylosing spondylitis patients but not in healthy controls.
Causality:No
Causal Description:
Clinical-realted Application:Patients in the high lncRNA NKILA level group had significantly longer length of treatment and higher re-hospitalization rate at 3 years after discharge.