Entry Detail


General Information

Database ID: LDA0015928
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MRPL20-AS1
Full Name:MRPL20 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:1
Strand:+
Coordinate:
Start Site(bp):1399530End Site(bp):1402046
External Links:
Ensembl ID:ENSG00000224870
Ensembl Transcript ID:N/A
Entrez Gene:148413.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050848D020181
Disease Name:obstructive sleep apneaSleep Apnea, Obstructive
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep.A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
Alias:obstructive sleep apnea syndromeSleep Apnea, Obstructive//Apneas, Obstructive Sleep//Obstructive Sleep Apneas//Sleep Apneas, Obstructive//Obstructive Sleep Apnea Syndrome//Obstructive Sleep Apnea//OSAHS//Syndrome, Sleep Apnea, Obstructive//Sleep Apnea Syndrome, Obstructive//Apnea, Obstructive Sleep//Sleep Apnea Hypopnea Syndrome//Syndrome, Obstructive Sleep Apnea//Upper Airway Resistance Sleep Apnea Syndrome//Syndrome, Upper Airway Resistance, Sleep Apnea

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:

 

Reference

[1] PubMed ID:35988669
Disease Name:Sleep Apnea, Obstructive
Sample:OSAS patients
Dysfunction Pattern:Regulation
Validated Method:qPCR//RNA-seq
Description:We found that three lncRNAs were significantly dysregulated, of which MRPL20-AS1 was the most significant. In a larger cohort of 22 OSAS patients, MRPL20-AS1 was inversely correlated with the apnea-hypopnea index (AHI). This indicates that OSAS patients with higher AHI levels and therefore more severe OSAS had lower levels of MRPL20-AS1 in the blood.
Causality:No
Causal Description:
Clinical-realted Application: