Entry Detail


General Information

Database ID: LDA0015932
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MEG3
Full Name:maternally expressed 3
Category:LncRNA
Species:Homo sapiens
Synonyms:FP504|GTL2|LINC00023|NCRNA00023|PRO0518|PRO2160|onco-lncRNA-83|prebp1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100826108End Site(bp):100861026
External Links:
Ensembl ID:ENSG00000214548
Ensembl Transcript ID:ENSG00000214548
Entrez Gene:55384.0
NONCODE ID:N/A
RefSeq Accession:NR_003531.3

 

ncRNA Association Statistics

Total Associated Disease Number:114   
More Information
Causal Disease Number:78
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Sepsis  (Score: 1)
Glioma  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Sepsis  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7147D013167
Disease Name:ankylosing spondylitisSpondylitis, Ankylosing
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
Alias:Bekhterev syndrome//Bekhterev's disease//Marie-Strumpell diseaseSpondylitis, Ankylosing//Bechterew's Disease//Bechterews Disease//Marie-Struempell Disease//Marie Struempell Disease//Spondylarthritis Ankylopoietica//Spondyloarthritis Ankylopoietica//Ankylosing Spondylitis//Ankylosing Spondylarthritis//Ankylosing Spondylarthritides//Spondylarthritides, Ankylosing//Spondylarthritis, Ankylosing//Ankylosing Spondyloarthritis//Ankylosing Spondyloarthritides//Spondyloarthritides, Ankylosing//Spondyloarthritis, Ankylosing//Spondylitis Ankylopoietica//Bechterew Disease//Rheumatoid Spondylitis//Spondylitis, Rheumatoid

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
hsa_circ_0056558  (Score: 0.731059)
hsa_circ_0003307  (Score: 0.731059)
hsa_circ_0056558  (Score: 0.731059)
hsa_circ_0003307  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:30651794
Disease Name:Spondylitis, Ankylosing
Sample:blood
Dysfunction Pattern:Expression[lower expressed]
Validated Method:qRT-PCR
Description:The results indicated that MEG3 was downregulated in ankylosing spondylitis patients compared with that in healthy controls.
Causality:No
Causal Description:
Clinical-realted Application:In addition, patients with higher expression levels of MEG3 had a shorter hospitalization time and a lower re-hospitalization rate within 2 years after discharge It was concluded that lncRNA MEG3 is downregulated in ankylosing spondylitis patients and is associated with disease activity, time of hospitalization and disease duration.

[2] PubMed ID:31894531
Disease Name:Spondylitis, Ankylosing
Sample:AS patients
Dysfunction Pattern:interaction[targeting miR-146a]
Validated Method:qRT-PCR//Luciferase Report Assay//RIP
Description:MEG3 was downregulated in AS patients, negatively correlated with the levels of IL-1β, IL-6, and TNF-α, and blocked the inflammatory response of AS. LncRNA MEG3 plays an anti-inflammatory role in AS partially through targeting miR-146a, which provides a potential new means for the treatment of AS patients.
Causality:No
Causal Description:
Clinical-realted Application: