| [1] PubMed ID: | 29257348 |
| Disease Name: | Respiratory Syncytial Virus Infections |
| Sample: | RSV‑infected patients and in BEAS‑2B cells infected with RSV |
| Dysfunction Pattern: | Regulation(TLR4‑dependent p38 MAPK and NF‑κB signaling) |
| Validated Method: | qRT-PCR//Transfection//Western Blot |
| Description: | The findings of the present study demonstrated that the expression level of lncRNA MEG3 was reduced in the NPA samples of RSV?infected patients and in BEAS?2B cells infected with RSV. In vitro transfection revealed increased mRNA expression levels of toll?like receptor 4 (TLR4), tumor necrosis factor?α (TNFα) and interleukin (IL)?8 following RSV infection in BEAS?2B cells. Additionally, ectopic expression of MEG3 reduced the expression level of TLR4, subsequently suppressing the mRNA expression levels of TNFα and IL?8, indicating the protective role of MEG3 in the process of RSV infection. It is of note, that RSV infection?induced p38 mitogen activated protein kinase (MAPK) and nuclear factor?κB (NF?κB) activation was partly abolished by overexpression of MEG3. |
| Causality: | No |
| Causal Description: | |
| Clinical-realted Application: | |