Entry Detail

General Information

Database ID: LDA0015951
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:METTL14
Full Name:methyltransferase 14, N6-adenosine-methyltransferase subunit
Category:LncRNA
Species:Homo sapiens
Synonyms:hMETTL14
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):118685392End Site(bp):118715430
External Links:
Ensembl ID:ENSG00000145388
Ensembl Transcript ID:N/A
Entrez Gene:57721.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3393D003327
Disease Name:coronary artery diseaseCoronary Disease
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Alias:CHD//Coronary disease//coronary arteriosclerosis//coronary heart diseaseCoronary Disease//Coronary Diseases//Disease, Coronary//Diseases, Coronary//Coronary Heart Disease//Coronary Heart Diseases//Disease, Coronary Heart//Diseases, Coronary Heart//Heart Disease, Coronary//Heart Diseases, Coronary

 

Disease Association Statistics

Total Associated ncRNA Number:44   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
EZR-AS1  (Score: 0.731059)
LOXL1-AS1  (Score: 0.731059)
SENCR  (Score: 0.731059)
circCHFR  (Score: 0.731059)
THRIL  (Score: 0.731059)
EZR-AS1  (Score: 0.731059)
LOXL1-AS1  (Score: 0.731059)
SENCR  (Score: 0.731059)
circCHFR  (Score: 0.731059)
THRIL  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:35235104
Disease Name:Coronary Disease
Sample:506 patients and 506 healthy subjects
Dysfunction Pattern:Interaction(rs4834698, rs17050450 )
Validated Method:Genotyping
Description:Our study showed that GAS5 rs17359906 (OR 2.32, p = 0.020) and rs75315904 (OR 0.41, p = 0.039) were related to the risk of CHD in females. ESR1 rs6927072 (OR 1.76, p = 0.007) and rs4870061 (OR 0.74, p = 0.036) correlated with CHD risk in age ≤ 60 years. GAS5 rs17359906 (OR 0.10, p = 0.032) and ESR1 rs3020308 (OR 2.73, p = 0.041) were associated with an increased susceptibility to CHD in smokers. We also found that METTL14 rs4834698 (OR 1.57, p = 0.044) and ESR1 rs4870061 (OR 0.62, p = 0.040) were associated with CHD susceptibility in non-drinkers. Besides, METTL14 rs17050450 (OR 0.48, p = 0.029) and ESR1 rs3853248 (OR 1.61, p = 0.018) had the susceptibility of CHD patients with diabetes. Our study indicated that GAS5/METTL14/ESR1 polymorphisms were associated with CHD risk, which might provide a new understanding of CHD in a Chinese population.
Causality:No
Causal Description:
Clinical-realted Application: