Entry Detail

General Information

Database ID: LDA0015958
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MEG8
Full Name:maternally expressed 8, small nucleolar RNA host gene
Category:LncRNA
Species:Homo sapiens
Synonyms:Bsr|Irm|LINC00024|NCRNA00024|Rian|SNHG23|SNHG24|lnc-MGC
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):100889649End Site(bp):100999113
External Links:
Ensembl ID:ENSG00000225746
Ensembl Transcript ID:N/A
Entrez Gene:79104.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Hemangioma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Wilms Tumor  (Score: 0.731059)
Myocardial Reperfusion Injury  (Score: 0.731059)
Bone-Invasive Pituitary Adenomas  (Score: 0.731059)
Hemangioma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050908D009190
Disease Name:myelodysplastic syndromeMyelodysplastic Syndromes
Category:Disease OntologyMeSH
Type:Hemic and Lymphatic Diseases
Define:A bone marrow cancer that is characterized by under production of white blood cells, red blood cells and platelets.Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.
Alias:Myelodysplastic Syndromes//Myelodysplastic Syndrome//Syndrome, Myelodysplastic//Syndromes, Myelodysplastic//Dysmyelopoietic Syndromes//Dysmyelopoietic Syndrome//Syndrome, Dysmyelopoietic//Syndromes, Dysmyelopoietic//Hematopoetic Myelodysplasia//Hematopoetic Myelodysplasias//Myelodysplasia, Hematopoetic//Myelodysplasias, Hematopoetic

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
BCYRN1  (Score: 0.731059)
BCYRN1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:32977510
Disease Name:Myelodysplastic Syndromes
Sample:bone marrow
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//Microarray
Description:Of the functionally described lncRNAs, we detected the upregulation of H19, EMCN-IT1, WT1-AS, MEG8, and PVT1 and the downregulation of ST6GAL2-IT1 and U6.
Causality:No
Causal Description:
Clinical-realted Application: