Entry Detail

General Information

Database ID: LDA0015970
Species: Homo sapiens
Confidence Score: 0.548294
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:MALAT1
Full Name:metastasis associated lung adenocarcinoma transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):65497738End Site(bp):65506516
External Links:
Ensembl ID:ENSG00000251562
Ensembl Transcript ID:N/A
Entrez Gene:378938.0
NONCODE ID:N/A
RefSeq Accession:NR_002819.4

 

ncRNA Association Statistics

Total Associated Disease Number:204   
More Information
Causal Disease Number:132
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Coronary Artery Disease  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
tongue squamous cell carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3121D005706
Disease Name:gallbladder cancerGallbladder Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A biliary tract cancer that is located_in the gallbladder.Tumors or cancer of the gallbladder.
Alias:gallbladder Ca//gallbladder neoplasm//localized malignant gallbladder neoplasm//malignant neoplasm of gallbladder//malignant tumor of the gallbladder//malignant tumour of gallbladder//tumor of the gallbladderGallbladder Neoplasms//Gallbladder Neoplasm//Neoplasm, Gallbladder//Neoplasms, Gallbladder//Cancer of Gallbladder//Gallbladder Cancers//Gallbladder Cancer//Cancer, Gallbladder//Cancers, Gallbladder//Gall Bladder Cancer//Bladder Cancer, Gall//Bladder Cancers, Gall//Cancer, Gall Bladder//Cancers, Gall Bladder//Gall Bladder Cancers//Cancer of the Gallbladder

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:38
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.999893)
PVT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01410  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
RP11-147L13.8  (Score: 0.731059)
HOXA-AS2  (Score: 0.731059)
EPIC1  (Score: 0.731059)
FIRRE  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:
Weak Evidence:Microarray

 

Reference

[1] PubMed ID:31174563
Disease Name:Gallbladder Neoplasms
Sample:GBC tissues and cell lines
Dysfunction Pattern:Interaction[ABI3BP ]
Validated Method:Microarray
Description:Microarray-based analysis initially provided data suggesting that the expression of MALAT1 was up-regulated while that of the ABI family member 3 binding protein (ABI3BP) was down-regulated in GBC tissues and cell lines. The results confirmed that the cancer prevention effects triggered by restored ABI3BP and depleted MALAT1 as evidenced by suppressed cell growth and enhanced cell senescence. MALAT1 was observed to down-regulate ABI3BP expression through recruitment of the enhancer of zeste homolog 2 (EZH2) to the ABI3BP promoter region while the silencing of MALAT1 or suppression of H3K27 methylation was observed to promote the expression of ABI3BP. Furthermore, GBC patients with high expression of MALAT1 indicated poor prognosis.
Causality:No
Causal Description:
Clinical-realted Application: