Entry Detail

General Information

Database ID: LDA0016102
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00926
Full Name:long intergenic non-protein coding RNA 926
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):57300365End Site(bp):57307769
External Links:
Ensembl ID:ENSG00000247982
Ensembl Transcript ID:N/A
Entrez Gene:283663.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2055D013313
Disease Name:post-traumatic stress disorderStress Disorders, Post-Traumatic
Category:Disease OntologyMeSH
Type:Mental Disorders
Define:An anxiety disorder which results from a traumatic experience that results in psychological trauma.A class of traumatic stress disorders with symptoms that last more than one month.
Alias:traumatic neurosisStress Disorders, Post-Traumatic//Post-Traumatic Stress Disorder//Stress Disorder, Post-Traumatic//Neuroses, Post-Traumatic//Neuroses, Post Traumatic//Post-Traumatic Neuroses//PTSD//Neuroses, Posttraumatic//Posttraumatic Neuroses//Post-Traumatic Stress Disorders//Post Traumatic Stress Disorders//Posttraumatic Stress Disorders//Posttraumatic Stress Disorder//Stress Disorder, Posttraumatic//Stress Disorders, Posttraumatic//Post Traumatic Stress Disorder//Stress Disorder, Post Traumatic//Delayed Onset Post-Traumatic Stress Disorder//Delayed Onset Post Traumatic Stress Disorder//Chronic Post-Traumatic Stress Disorder//Chronic Post Traumatic Stress Disorder//Moral Injury//Injury, Moral//Moral Injuries//Acute Post-Traumatic Stress Disorder//Acute Post Traumatic Stress Disorder

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:35551428
Disease Name:Stress Disorders, Post-Traumatic
Sample:PTSD sample
Dysfunction Pattern:Interaction(MLL1/IFNG and IL17A)
Validated Method:ELISA//RNA-seq
Description:Increased H3K4me3 resulted from LINC00926, which we found to be upregulated in the PTSD sample, bringing in histone methyltransferase, MLL1, onto WNT10B promotor leading to the introduction of H3K4 trimethylation. The addition of recombinant human WNT10B to pre-activated peripheral blood mononuclear cells (PBMCs) led to increased expression of inflammatory genes such as IFNG and IL17A, suggesting that WNT10B is involved in their upregulation. Together, our data suggested that LINC00926 interacts physically with MLL1 and thereby controls the expression of IFNG and IL17A. This is the first time a long non-coding RNA is shown to regulate the expression of WNT10B and consequently inflammation. This observation has high relevance to our understanding of disease mechanisms of PTSD and comorbidities associated with PTSD.
Causality:No
Causal Description:
Clinical-realted Application: