Entry Detail

General Information

Database ID: LDA0016347
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:IARS1
Full Name:isoleucyl-tRNA synthetase 1
Category:LncRNA
Species:Homo sapiens
Synonyms:GRIDHH|IARS|ILERS|ILRS|IRS|PRO0785
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):92210207End Site(bp):92293697
External Links:
Ensembl ID:ENSG00000196305
Ensembl Transcript ID:N/A
Entrez Gene:3376.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1793D010190
Disease Name:pancreatic cancerPancreatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An endocrine gland cancer located_in the pancreas.Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Alias:Ca body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas//pancreas neoplasm//pancreatic neoplasm//pancreatic tumorPancreatic Neoplasms//Neoplasm, Pancreatic//Pancreatic Neoplasm//Pancreas Neoplasms//Neoplasm, Pancreas//Neoplasms, Pancreas//Pancreas Neoplasm//Neoplasms, Pancreatic//Cancer of Pancreas//Pancreas Cancers//Pancreas Cancer//Cancer, Pancreas//Cancers, Pancreas//Pancreatic Cancer//Cancer, Pancreatic//Cancers, Pancreatic//Pancreatic Cancers//Cancer of the Pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:322   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
CASC2  (Score: 0.999893)
CASC2  (Score: 0.999893)
LINC00460  (Score: 0.999893)
LINC00460  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30064461
Disease Name:Pancreatic Neoplasms
Sample:pancreatic cancer tissues and plasma exosomes
Dysfunction Pattern:Expression[highly expressed]
Validated Method:PCR//Western Blot
Description:circ-IARS expression was up-regulated in pancreatic cancer tissues and in plasma exosomes of patients with metastatic disease.
Causality:No
Causal Description:
Clinical-realted Application:Circ-IARS was found to enter HUVECs through exosomes and promote tumor invasion and metastasis. Circ-IARS expression was positively correlated with liver metastasis, vascular invasion, and tumor-node-metastasis (TNM) stage and negatively correlated with postoperative survival time.