Entry Detail

General Information

Database ID: LDA0016350
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HULC
Full Name:hepatocellular carcinoma up-regulated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HCCAT1|LINC00078|NCRNA00078
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):8652209End Site(bp):8653846
External Links:
Ensembl ID:ENSG00000285219
Ensembl Transcript ID:N/A
Entrez Gene:728655.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Liver Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9408
Disease Name:acute myocardial infarction
Category:Disease Ontology
Type:Cardiovascular Diseases
Define:
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:70   
More Information
Causal ncRNA Number:22
Network:
Top Causal ncRNAs:
MIAT  (Score: 0.985791)
Malat1  (Score: 0.985791)
MIAT  (Score: 0.985791)
TTTY15  (Score: 0.985791)
TTTY15  (Score: 0.985791)
Malat1  (Score: 0.985791)
NEAT1  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
LINC00152  (Score: 0.731059)
lnc-Chaer  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:35246050
Disease Name:acute myocardial infarction
Sample:80 AMI patients and 36 healthy volunteers
Dysfunction Pattern:Regulation
Validated Method:qRT-PCR
Description:ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors.
Causality:No
Causal Description:
Clinical-realted Application:ROC analysis reveals the superiority of TTTY15 and HULC as biomarkers against conventional AMI biomarkers CKMB (AUC of TTTY15: 0.915 versus CKMB: 0.768 versus TnT: 0.869); AUC of HULC: 0.905 versus CKMB: 0.768 versus TnT: 0.869). Regression and correlation analysis indicates that TTTY15 and HULC may be one of the contributing factors to AMI and related to accepted risk factors.