Entry Detail

General Information

Database ID: LDA0016393
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOTTIP
Full Name:HOXA distal transcript antisense RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HOXA-AS6|HOXA13-AS1|NCRNA00213
Chromosome:7
Strand:+
Coordinate:
Start Site(bp):27200421End Site(bp):27207259
External Links:
Ensembl ID:ENSG00000243766
Ensembl Transcript ID:N/A
Entrez Gene:100316868.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:30
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1240D007938
Disease Name:leukemiaLeukemia
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
Alias:Leukemia//Leukemias//Leucocythaemia//Leucocythaemias//Leucocythemia//Leucocythemias

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
SNHG16  (Score: 0.731059)
hsa_circ_0121582  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0121582  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:35180428
Disease Name:Leukemia
Sample:AML genome
Dysfunction Pattern:Regulation( CTCF chromatin boundary activity and TAD integrity)
Validated Method:In Vivo Experiment//qRT-PCR//RNA-seq
Description:HOTTIP lncRNA is highly expressed in acute myeloid leukemia (AML) driven by MLL rearrangements or NPM1 mutations to mediate HOXA topologically associated domain (TAD) formation and drive aberrant transcription. Thus, HOTTIP-mediated R-loop formation directly reinforces CTCF chromatin boundary activity and TAD integrity to drive oncogene transcription and leukemia development.
Causality:No
Causal Description:
Clinical-realted Application: