Entry Detail

General Information

Database ID: LDA0016402
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HULC
Full Name:hepatocellular carcinoma up-regulated long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:HCCAT1|LINC00078|NCRNA00078
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):8652209End Site(bp):8653846
External Links:
Ensembl ID:ENSG00000285219
Ensembl Transcript ID:N/A
Entrez Gene:728655.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:54   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Liver Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3369
Disease Name:Ewing sarcoma
Category:Disease Ontology
Type:Neoplasms
Define:A connective tissue cancer that has_material_basis_in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm.
Alias:Ewing's family localized tumor//Ewing's sarcoma/peripheral primitive neuroectodermal tumor//Ewing's tumor//Ewings sarcoma//Ewings sarcoma-primitive neuroectodermal tumor//PNET of Thoracopulmonary Region//localized Ewing sarcoma//localized Ewing's sarcoma//localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor//localized Ewing's tumor//localized peripheral primitive neuroectodermal tumor//peripheral primitive neuroectodermal tumor

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31639426
Disease Name:Ewing sarcoma
Sample:ewing sarcoma cells
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//Luciferase Report Assay//Western Blot
Description:Herein, by performing a high-throughput screening we identify the lncRNA HULC (Highly Upregulated in Liver Cancer) as a prominent target of YK-4-279 activity in ES cells. Mechanistically, we find that HULC promotes the expression of TWIST1 oncogene by sponging miR-186. Downregulation of HULC upon treatment with YK-4-279 reduces the expression of TWIST1 by unleashing miR-186 and favoring its binding to TWIST1 transcripts.
Causality:No
Causal Description:
Clinical-realted Application: