Entry Detail

General Information

Database ID: LDA0016420
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:HOXB-AS3
Full Name:HOXB cluster antisense RNA 3
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:17
Strand:+
Coordinate:
Start Site(bp):48590420End Site(bp):48606414
External Links:
Ensembl ID:ENSG00000233101
Ensembl Transcript ID:N/A
Entrez Gene:404266.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D023981
Disease Name:Sarcoma, Myeloid
Category:MeSH
Type:Neoplasms
Define:An extramedullary tumor of immature MYELOID CELLS or MYELOBLASTS. Granulocytic sarcoma usually occurs with or follows the onset of ACUTE MYELOID LEUKEMIA.
Alias:Sarcoma, Myeloid//Myeloid Sarcomas//Sarcomas, Myeloid//Myeloid Sarcoma//Myeloid Cell Tumor, Extramedullary//Chloroma//Chloromas//Extramedullary Myeloid Cell Tumor//Sarcoma, Granulocytic//Granulocytic Sarcoma//Granulocytic Sarcomas//Sarcomas, Granulocytic

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:BrdU
Weak Evidence:

 

Reference

[1] PubMed ID:31234830
Disease Name:Sarcoma, Myeloid
Sample:
Dysfunction Pattern:Regulated[up-regulated]
Validated Method:BrdU//Microarray
Description:Mechanistically, HOXB-AS3 potentiated the expressions of several key factors in cell cycle progression and DNA replication without affecting the expressions of HOX genes. In AML, patients with higher HOXB-AS3 expression had shorter survival than those with lower HOXB-AS3 expression (median overall survival (OS), 17.7 months versus not reached, P < 0.0001; median relapse-free survival, 12.9 months versus not reached, P = 0.0070).
Causality:No
Causal Description:
Clinical-realted Application:In AML, patients with higher HOXB-AS3 expression had shorter survival than those with lower HOXB-AS3 expression (median overall survival (OS), 17.7 months versus not reached, P < 0.0001; median relapse-free survival, 12.9 months versus not reached, P = 0.0070). In MDS, patients with higher HOXB-AS3 expression also had adverse prognosis compared with those with lower HOXB-AS3 expression (median OS, 14.6 months versus 42.4 months, P = 0.0018). The prognostic significance of HOXB-AS3 expression was validated in the TCGA AML cohort and another MDS cohort from our institute.