Entry Detail

General Information

Database ID: LDA0016485
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KCNQ1OT1
Full Name:KCNQ1 opposite strand/antisense transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:KCNQ1-AS2|KCNQ10T1|Kncq1|KvDMR1|KvLQT1-AS|LIT1|NCRNA00012
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):2608328End Site(bp):2699998
External Links:
Ensembl ID:ENSG00000269821
Ensembl Transcript ID:N/A
Entrez Gene:10984.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:64   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D003928
Disease Name:Diabetic Nephropathies
Category:MeSH
Type:Urogenital Diseases
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Alias:Diabetic Nephropathies//Nephropathies, Diabetic//Nephropathy, Diabetic//Diabetic Nephropathy//Diabetic Kidney Disease//Diabetic Kidney Diseases//Kidney Disease, Diabetic//Kidney Diseases, Diabetic//Diabetic Glomerulosclerosis//Glomerulosclerosis, Diabetic//Intracapillary Glomerulosclerosis//Nodular Glomerulosclerosis//Glomerulosclerosis, Nodular//Kimmelstiel-Wilson Syndrome//Kimmelstiel Wilson Syndrome//Syndrome, Kimmelstiel-Wilson//Kimmelstiel-Wilson Disease//Kimmelstiel Wilson Disease

 

Disease Association Statistics

Total Associated ncRNA Number:72   
More Information
Causal ncRNA Number:58
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999998)
MALAT1  (Score: 0.999998)
MIAT  (Score: 0.985791)
MIAT  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
circHIPK3  (Score: 0.985791)
circHIPK3  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
CASC2  (Score: 0.731059)
CASC2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qPCR//H&E Staining//IF
Weak Evidence:

 

Reference

[1] PubMed ID:35422925
Disease Name:Diabetic Nephropathies
Sample:T2D group
Dysfunction Pattern:Regulation(MEK-5 and ERK2)
Validated Method:IF//qPCR//H&E Staining//Western Blot
Description:The relative expression of LncRNA KCNQ1OT1, MEK-5 and ERK2 in the control group was lower than that of the T2D group and DN group (P<0.05), and the relative expression of LncRNA KCNQ1OT1 in T2D group was lower than that of DN group (P<0.05). The expression of LncRNA KCNQ1OT1 was positively-correlated with MEK-5 and ERK2 (P<0.05). The relative expression of LncRNA KCNQ1OT1, MEK-5, and ERK2 in renal tissues of the DN group was higher than those in the control group and diabetes group (P<0.05).
Causality:No
Causal Description:
Clinical-realted Application: