Entry Detail

General Information

Database ID: LDA0016488
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KCNQ1OT1
Full Name:KCNQ1 opposite strand/antisense transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:KCNQ1-AS2|KCNQ10T1|Kncq1|KvDMR1|KvLQT1-AS|LIT1|NCRNA00012
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):2608328End Site(bp):2699998
External Links:
Ensembl ID:ENSG00000269821
Ensembl Transcript ID:N/A
Entrez Gene:10984.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:64   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8947D003930
Disease Name:diabetic retinopathyDiabetic Retinopathy
Category:Disease OntologyMeSH
Type:Eye Diseases
Define:Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Alias:Retinal abnormality - diabetes-relatedDiabetic Retinopathy//Diabetic Retinopathies//Retinopathies, Diabetic//Retinopathy, Diabetic

 

Disease Association Statistics

Total Associated ncRNA Number:34   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
ZNF503-AS1  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
FLG-AS1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
LINC00673  (Score: 0.731059)
SNHG16  (Score: 0.731059)
VEAL2  (Score: 0.731059)
MAP4K2  (Score: 0.731059)
TDRG1  (Score: 0.731059)
SNHG7  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30784065
Disease Name:Diabetic Retinopathy
Sample:retinal endothelial cells
Dysfunction Pattern:Interaction[ sponge miR-1470 ]
Validated Method:qRT-PCR//Luciferase Report Assay
Description:In this study, regarding quantitative reverse transcription polymerase chain reaction assay, KCNQ1OT1 level was upregulated while microRNA-1470 (miR-1470) was decreased in DR patients and human retinal endothelial cells.The results suggested that KCNQ1OT1 could sponge miR-1470 and further regulate EGFR in DR.
Causality:No
Causal Description:
Clinical-realted Application: