Entry Detail

General Information

Database ID: LDA0016490
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KCNQ1OT1
Full Name:KCNQ1 opposite strand/antisense transcript 1
Category:LncRNA
Species:Homo sapiens
Synonyms:KCNQ1-AS2|KCNQ10T1|Kncq1|KvDMR1|KvLQT1-AS|LIT1|NCRNA00012
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):2608328End Site(bp):2699998
External Links:
Ensembl ID:ENSG00000269821
Ensembl Transcript ID:N/A
Entrez Gene:10984.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:64   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000375
Disease Name:Aging
Category:MeSH
Type:Physiological Phenomena
Define:The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Alias:Aging//Senescence//Biological Aging//Aging, Biological

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
EPB41L4A-AS1  (Score: 0.731059)
circGSE1  (Score: 0.731059)
EPB41L4A-AS1  (Score: 0.731059)
circGSE1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//Immunoblotting
Weak Evidence:

 

Reference

[1] PubMed ID:35163809
Disease Name:Aging
Sample:human lung fibroblast IMR-90 cells
Dysfunction Pattern:Interaction(miR-760)
Validated Method:qRT-PCR//Transfection//Immunoblotting
Description:Additionally, KCNQ1OT1 was downregulated during replicative senescence, and its silencing induced senescence in human lung fibroblast IMR-90 cells. Additionally, an miR-760 mimic suppressed KCNQ1OT1-mediated CK2α upregulation, indicating that KCNQ1OT1 upregulated CK2α by sponging miR-760.
Causality:No
Causal Description:
Clinical-realted Application: