Entry Detail

General Information

Database ID: LDA0016522
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:KLK8
Full Name:kallikrein related peptidase 8
Category:LncRNA
Species:Homo sapiens
Synonyms:HNP|NP|NRPN|PRSS19|TADG14
Chromosome:19
Strand:-
Coordinate:
Start Site(bp):50996008End Site(bp):51001604
External Links:
Ensembl ID:ENSG00000129455
Ensembl Transcript ID:N/A
Entrez Gene:11202.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:219D003110
Disease Name:colon cancerColonic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A colorectal cancer that is located_in the colon.Tumors or cancer of the COLON.
Alias:Colonic Neoplasms//Colonic Neoplasm//Neoplasm, Colonic//Neoplasms, Colonic//Colon Neoplasms//Colon Neoplasm//Neoplasm, Colon//Neoplasms, Colon//Cancer of Colon//Colon Cancers//Colon Cancer//Cancer, Colon//Cancers, Colon//Cancer of the Colon//Colonic Cancer//Cancer, Colonic//Cancers, Colonic//Colonic Cancers//Colon Adenocarcinoma//Adenocarcinoma, Colon//Adenocarcinomas, Colon//Colon Adenocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:272   
More Information
Causal ncRNA Number:210
Network:
Top Causal ncRNAs:
MALAT1  (Score: 1)
MALAT1  (Score: 1)
HOTAIR  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
circPPP1R12A  (Score: 0.985791)
CASC9  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:34271345
Disease Name:Colonic Neoplasms
Sample:colon cancer tissues
Dysfunction Pattern:Expression(markedly upregulated)
Validated Method:qRT-PCR//Western Blot
Description:KLK8 was markedly upregulated in colon cancer tissues in comparison with normal tissues, and its expression was related to tumor size, TNM stage, and metastasis, and positively correlated with the expression of CSCs-related genes in colon cancer tissues.
Causality:No
Causal Description:
Clinical-realted Application:KLK8 was markedly upregulated in colon cancer tissues in comparison with normal tissues, and its expression was related to tumor size, TNM stage, and metastasis, and positively correlated with the expression of CSCs-related genes in colon cancer tissues.