Entry Detail

General Information

Database ID: LDA0016536
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC02200
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:ENSG00000250358
Ensembl Transcript ID:N/A
Entrez Gene:N/A
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Sinonasal Squamous Cell Carcinoma  (Score: 0.731059)
Sinonasal Squamous Cell Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2876
Disease Name:laryngeal squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A laryngeal carcinoma that has_material_basis_in squamous cells.
Alias:Epidermoid carcinoma of the Larynx//squamous cell carcinoma of larynx

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
LINC01638  (Score: 0.731059)
AC023794.4-201  (Score: 0.731059)
hsa_circ_0006232  (Score: 0.731059)
hsa_circ_0067934  (Score: 0.731059)
TACR3-AS1  (Score: 0.731059)
LINC01638  (Score: 0.731059)
AC023794.4-201  (Score: 0.731059)
hsa_circ_0006232  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:32363688
Disease Name:laryngeal squamous cell carcinoma
Sample:LSCC tissues and cell lines
Dysfunction Pattern:regulation[ RP11-159K7.2/miR-206/DNMT3A axis]
Validated Method:qRT-PCR
Description:Briefly, in situ hybridization (ISH) and real-time quantitative PCR (RT-qPCR) showed higher expression of RP11-159K7.2 in LSCC tissues and cell lines.Mechanically, we found that RP11-159K7.2 could positively regulate the expression of DNMT3A by sponging miR-206. In addition, a feedback loop was also discovered between DNMT3A and miR-206.
Causality:No
Causal Description:
Clinical-realted Application:Patients with low expression level of RP11-159K7.2 lived longer compared to those with high expression of RP11-159K7.2 (χ2 = 39.111, ***P < 0.001).