Entry Detail


General Information

Database ID: LDA0016836
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LNCNEF
Full Name:lncRNA neighboring enhancer of FOXA2
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01384|lncRNA-NEF
Chromosome:20
Strand:-
Coordinate:
Start Site(bp):22587522End Site(bp):22607517
External Links:
Ensembl ID:ENSG00000237396
Ensembl Transcript ID:N/A
Entrez Gene:101929685.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:7147D013167
Disease Name:ankylosing spondylitisSpondylitis, Ankylosing
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
Alias:Bekhterev syndrome//Bekhterev's disease//Marie-Strumpell diseaseSpondylitis, Ankylosing//Bechterew's Disease//Bechterews Disease//Marie-Struempell Disease//Marie Struempell Disease//Spondylarthritis Ankylopoietica//Spondyloarthritis Ankylopoietica//Ankylosing Spondylitis//Ankylosing Spondylarthritis//Ankylosing Spondylarthritides//Spondylarthritides, Ankylosing//Spondylarthritis, Ankylosing//Ankylosing Spondyloarthritis//Ankylosing Spondyloarthritides//Spondyloarthritides, Ankylosing//Spondyloarthritis, Ankylosing//Spondylitis Ankylopoietica//Bechterew Disease//Rheumatoid Spondylitis//Spondylitis, Rheumatoid

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
hsa_circ_0056558  (Score: 0.731059)
hsa_circ_0003307  (Score: 0.731059)
hsa_circ_0056558  (Score: 0.731059)
hsa_circ_0003307  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:35894706
Disease Name:Spondylitis, Ankylosing
Sample:synovial fluid of AS patients
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR//Transfection//Western Blot
Description: Our study observed that lncRNA-NEF expression was upregulated in synovial fluid of AS patients and significantly correlated with the ASDAS 1-4, BASDAI, erythrocyte sedimentation rate (ESR), and C-reactive protein level (p < .05). Treatment with nonsteroidal anti-inflammatory drugs significantly downregulated lncRNA-NEF expression (p < .01).
Causality:No
Causal Description:
Clinical-realted Application:A 3-year follow-up showed that patients with high lncRNA-NEF levels had a high recurrence rate (hazard ratio = 2.266).