Entry Detail

General Information

Database ID: LDA0016845
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LNC-LBCS
Full Name:lncRNA bladder and prostate cancer suppressor, hnRNPK interacting
Category:LncRNA
Species:Homo sapiens
Synonyms:LBCS
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):19729421End Site(bp):19804759
External Links:
Ensembl ID:ENSG00000228412
Ensembl Transcript ID:N/A
Entrez Gene:100506885.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10283D011471
Disease Name:prostate cancerProstatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A male reproductive organ cancer that is located_in the prostate.Tumors or cancer of the PROSTATE.
Alias:NGP - new growth of prostate//hereditary prostate cancer//malignant tumor of the prostate//prostate cancer, familial//prostate neoplasm//prostatic cancer//prostatic neoplasm//tumor of the prostateProstatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

 

Disease Association Statistics

Total Associated ncRNA Number:566   
More Information
Causal ncRNA Number:414
Network:
Top Causal ncRNAs:
TUG1  (Score: 1)
SNHG1  (Score: 1)
MALAT1  (Score: 1)
NORAD  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
SNHG3  (Score: 1)
MALAT1  (Score: 1)
SNHG1  (Score: 1)
NORAD  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qPCR//RIP//MTT//IHC//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:31221168
Disease Name:Prostatic Neoplasms
Sample:CRPC cells lines and tissues
Dysfunction Pattern:Interaction[hnRNPK]
Validated Method:RNA Pull-Down//Western Blot//qPCR//RIP//MTT//Microarray//IHC//ChIP
Description:The expression of Lnc-LBCS was lower in CRPC cells lines and tissues. Lnc-LBCS functions as a novel AR translational regulator that suppresses castration resistance of prostate cancer by interacting with hnRNPK. This sheds a new insight into the regulation of CRPC by lncRNA mediated AR activation and LBCS-hnRNPK-AR axis provides a promising approach to the treatment of CRPC.
Causality:No
Causal Description:
Clinical-realted Application:LBCS downregulation was correlated with higher Gleason Score, T stage and poor prognosis of PCa patients.