Entry Detail

General Information

Database ID: LDA0017400
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SOX2-OT
Full Name:SOX2 overlapping transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00043|SOX2OT
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):181056680End Site(bp):181742228
External Links:
Ensembl ID:ENSG00000242808
Ensembl Transcript ID:N/A
Entrez Gene:347689.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Laryngeal Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Multiple Myeloma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3907
Disease Name:lung squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A non-small cell lung carcinoma that has_material_basis_in the squamous cell.
Alias:Epidermoid cell carcinoma of the lung

 

Disease Association Statistics

Total Associated ncRNA Number:92   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
PITPNA-AS1  (Score: 0.985791)
PITPNA-AS1  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
MIR205HG  (Score: 0.985791)
LINC00519  (Score: 0.731059)
circTP63  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
ATB  (Score: 0.731059)
LINC00668  (Score: 0.731059)
MAGI2-AS3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30986097
Disease Name:lung squamous cell carcinoma
Sample:exosomes
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:Exosomal SOX2-OT was significantly upregulated in LSCC patients and showed the strongest power in detecting LSCC.
Causality:No
Causal Description:
Clinical-realted Application:The area under the ROC curve was 0.815, and the sensitivity and specificity were 76% and 73.17%, respectively. Moreover, exosomal SOX2-OT levels were significantly correlated with tumor size, TNM stage, and lymph node metastasis.