Entry Detail

General Information

Database ID: LDA0017401
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SOX2-OT
Full Name:SOX2 overlapping transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00043|SOX2OT
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):181056680End Site(bp):181742228
External Links:
Ensembl ID:ENSG00000242808
Ensembl Transcript ID:N/A
Entrez Gene:347689.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Laryngeal Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Multiple Myeloma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11946D000026
Disease Name:obsolete habitual abortionAbortion, Habitual
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:Three or more consecutive spontaneous abortions.
Alias:Aborter - recurrent//Habitual aborter//Habitual aborter - unspecified (disorder)//Habitual aborter NOS (disorder)//chronic spontaneous abortion//recurrent abortion (disorder)//recurrent miscarriageAbortion, Habitual//Habitual Abortion//Habitual Abortions//Abortion, Recurrent//Recurrent Abortion//Recurrent Abortions//Miscarriage, Recurrent//Recurrent Miscarriage//Recurrent Miscarriages//Recurrent Early Pregnancy Loss

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
lnc-CES1-1  (Score: 0.731059)
lnc-CES1-1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:31827385
Disease Name:Abortion, Habitual
Sample:blood
Dysfunction Pattern:Mutation[rs9839776 ]
Validated Method:Genotyping
Description: However, whether lncRNA SOX2OT polymorphisms are related to recurrent miscarriage susceptibility is unclear. Therefore, we investigated the relationship between the lncRNA SOX2OT rs9839776 C>T polymorphism and recurrent miscarriage susceptibility. We recruited 570 subjects with recurrent miscarriage and 578 healthy control subjects from a population in southern China and used the TaqMan method for genotyping. We found a significant association between the rs9839776 CT genotype in the SOX2OT gene and an increased risk for recurrent miscarriage (CT vs CC: adjusted OR = 1.357, 95%CI = 1.065 - 1.728, P = 0.0134). However, we did not observe any significant associations between the recurrent miscarriage risk and the number of miscarriages in different age groups. In conclusion, our study indicated that the rs9839776 CT genotype may contribute to an increased risk of recurrent miscarriage in the southern Chinese population and that rs9839776 may act as a prognostic biomarker in recurrent miscarriage patients. However, an experiment-based study with a larger sample size should be performed to confirm these results.
Causality:No
Causal Description:
Clinical-realted Application: