Entry Detail

General Information

Database ID: LDA0017521
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TCF21
Full Name:transcription factor 21
Category:LncRNA
Species:Homo sapiens
Synonyms:POD1|bHLHa23
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):133889113End Site(bp):133895537
External Links:
Ensembl ID:ENSG00000118526
Ensembl Transcript ID:N/A
Entrez Gene:6943.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3393D003324
Disease Name:coronary artery diseaseCoronary Artery Disease
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Alias:CHD//Coronary disease//coronary arteriosclerosis//coronary heart diseaseCoronary Artery Disease//Artery Disease, Coronary//Artery Diseases, Coronary//Coronary Artery Diseases//Left Main Coronary Artery Disease//Left Main Disease//Left Main Diseases//Left Main Coronary Disease//Coronary Arteriosclerosis//Arterioscleroses, Coronary//Coronary Arterioscleroses//Atherosclerosis, Coronary//Atheroscleroses, Coronary//Coronary Atheroscleroses//Coronary Atherosclerosis//Arteriosclerosis, Coronary

 

Disease Association Statistics

Total Associated ncRNA Number:134   
More Information
Causal ncRNA Number:24
Network:
Top Causal ncRNAs:
MALAT1  (Score: 1)
MALAT1  (Score: 1)
LINC00968  (Score: 0.985791)
LINC00968  (Score: 0.985791)
uc003pxg.1  (Score: 0.731059)
GAS5  (Score: 0.731059)
AGAP2-AS1  (Score: 0.731059)
circLDLR  (Score: 0.731059)
circNPHP4  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:34970358
Disease Name:Coronary Artery Disease
Sample:Serum
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR
Description:he serum level of CCHE1 was positively related to CAD severity and numbers of vessel lesions, while TCF21 displayed a negative relationship. During the 3-year follow-up, the incidence of cardiovascular events was 39.3% (59/150). CAD severity, numbers of vessel lesions, and serum levels of CCHE1 and TCF21 were independent factors influencing the occurrence of cardiovascular events in CAD patients.
Causality:No
Causal Description:
Clinical-realted Application:The serum level of CCHE1 was positively related to CAD severity and numbers of vessel lesions, while TCF21 displayed a negative relationship. During the 3-year follow-up, the incidence of cardiovascular events was 39.3% (59/150). CAD severity, numbers of vessel lesions, and serum levels of CCHE1 and TCF21 were independent factors influencing the occurrence of cardiovascular events in CAD patients.