Entry Detail

General Information

Database ID: LDA0017523
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TCEAL1
Full Name:cyclin dependent kinase inhibitor 1A
Category:LncRNA
Species:Homo sapiens
Synonyms:CAP20|CDKN1|CIP1|MDA-6|P21|SDI1|WAF1|p21CIP1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):36676463End Site(bp):36687332
External Links:
Ensembl ID:ENSG00000172465
Ensembl Transcript ID:N/A
Entrez Gene:1026.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Liver Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1993D012004
Disease Name:rectum cancerRectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A colorectal cancer that is located_in the rectum.Tumors or cancer of the RECTUM.
Alias:carcinoma of rectum//carcinoma of the rectum//malignant Rectal tumor//malignant neoplasm of rectum//malignant rectum tumor//malignant tumor of rectum//rectal cancerRectal Neoplasms//Neoplasm, Rectal//Rectal Neoplasm//Rectum Neoplasms//Neoplasm, Rectum//Rectum Neoplasm//Rectal Tumors//Rectal Tumor//Tumor, Rectal//Neoplasms, Rectal//Cancer of Rectum//Rectum Cancers//Rectal Cancer//Cancer, Rectal//Rectal Cancers//Rectum Cancer//Cancer, Rectum//Cancer of the Rectum

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
FEZF1-AS1  (Score: 0.731059)
SNHG17  (Score: 0.731059)
circTUBGCP3  (Score: 0.731059)
NKILA  (Score: 0.731059)
FEZF1-AS1  (Score: 0.731059)
SNHG17  (Score: 0.731059)
circTUBGCP3  (Score: 0.731059)
NKILA  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:32878005
Disease Name:Rectal Neoplasms
Sample:Rectal Cancer tissues
Dysfunction Pattern:Expression[lower expressed]
Validated Method:qRT-PCR
Description:LincRNA-p21 was downregulated in tumor versus normal tissue (p = 0.0012).
Causality:No
Causal Description:
Clinical-realted Application:CRC patients with high lincRNA-p21 expression had shorter DFS (p = 0.0372) and shorter OS (p = 0.0465). Of note, the major prognostic impact was observed in the subset of rectal cancer patients where patients with high lincRNA-p21 levels had worse DFS (p = 0.0226) and OS (p = 0.0457). Interestingly, rectal cancer patients with high lincRNA-p21 benefited from post-operative chemoradiotherapy, as indicated by a longer OS in the group of high lincRNA-p21 patients receiving post-operative chemoradiotherapy (p = 0.04). Finally, patients with high lincRNA-p21 levels in mesenteric vein (MV) had shorter OS (p = 0.0329).