Entry Detail

General Information

Database ID: LDA0017571
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:VDR
Full Name:vitamin D receptor
Category:LncRNA
Species:Homo sapiens
Synonyms:NR1I1|PPP1R163
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):47841537End Site(bp):47904994
External Links:
Ensembl ID:ENSG00000111424
Ensembl Transcript ID:N/A
Entrez Gene:7421.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080600D000086382
Disease Name:COVID-19COVID-19
Category:Disease OntologyMeSH
Type:Infections
Define:A Coronavirus infection that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2.A viral disorder generally characterized by high FEVER; COUGH; DYSPNEA; CHILLS; PERSISTENT TREMOR; MUSCLE PAIN; HEADACHE; SORE THROAT; a new loss of taste and/or smell (see AGEUSIA and ANOSMIA) and other symptoms of a VIRAL PNEUMONIA. In severe cases, a myriad of coagulopathy associated symptoms often correlating with COVID-19 severity is seen (e.g., BLOOD COAGULATION; THROMBOSIS; ACUTE RESPIRATORY DISTRESS SYNDROME; SEIZURES; HEART ATTACK; STROKE; multiple CEREBRAL INFARCTIONS; KIDNEY FAILURE; catastrophic ANTIPHOSPHOLIPID ANTIBODY SYNDROME and/or DISSEMINATED INTRAVASCULAR COAGULATION). In younger patients, rare inflammatory syndromes are sometimes associated with COVID-19 (e.g., atypical KAWASAKI SYNDROME; TOXIC SHOCK SYNDROME; pediatric multisystem inflammatory disease; and CYTOKINE STORM SYNDROME). A coronavirus, SARS-CoV-2, in the genus BETACORONAVIRUS is the causative agent.
Alias:2019 Novel Coronavirus (2019-nCoV)//2019-nCoV infection//Wuhan coronavirus infection//Wuhan seafood market pneumonia virus infectionCOVID-19//COVID 19//2019-nCoV Infection//2019 nCoV Infection//2019-nCoV Infections//Infection, 2019-nCoV//SARS-CoV-2 Infection//Infection, SARS-CoV-2//SARS CoV 2 Infection//SARS-CoV-2 Infections//2019 Novel Coronavirus Disease//2019 Novel Coronavirus Infection//COVID-19 Virus Infection//COVID 19 Virus Infection//COVID-19 Virus Infections//Infection, COVID-19 Virus//Virus Infection, COVID-19//COVID19//Coronavirus Disease 2019//Disease 2019, Coronavirus//Coronavirus Disease-19//Coronavirus Disease 19//Severe Acute Respiratory Syndrome Coronavirus 2 Infection//COVID-19 Virus Disease//COVID 19 Virus Disease//COVID-19 Virus Diseases//Disease, COVID-19 Virus//Virus Disease, COVID-19//SARS Coronavirus 2 Infection//2019-nCoV Disease//2019 nCoV Disease//2019-nCoV Diseases//Disease, 2019-nCoV//COVID-19 Pandemic//COVID 19 Pandemic//Pandemic, COVID-19//COVID-19 Pandemics

 

Disease Association Statistics

Total Associated ncRNA Number:116   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:34147082
Disease Name:COVID-19
Sample:peripheral blood
Dysfunction Pattern:Expression(lower expressed)
Validated Method:qRT-PCR
Description:Expression of SNHG6 was considerably lower in COVID-19 patients compared with control subjects (Ratio of mean expression (RME) = 0.22, P value = 7.04E-05) and in both female and male COVID-19 patients compared with sex-matched unaffected individuals (RME = 0.32, P value = 0.04 and RME = 0.16, P value = 0.000679683, respectively). However, its expression was similar among ICU-hospitalized and non-ICU patients. Similarly, expression of SNHG16 was lower in in COVID-19 patients compared with controls (RME = 0.20, P value = 5.94E-05) and in both female and male patients compared with sex-matched controls (RME = 0.32, P value = 0.04 and RME = 0.14, P value = 0.000496435, respectively) with no significant difference among ICU-hospitalized and non-ICU hospitalized patients. Expression of VDR was lower in COVID-19 patients compared with controls (RME = 0.42, P value = 0.04) and in male patients compared with male controls (RME = 0.27, P value = 0.02). Yet, expression of VDR was statistically similar between female subgroups and between ICU-hospitalized and non-ICU hospitalized patients. Expression levels CYP27B, Linc00511 and Linc00346 were similar among COVID-19 patients and healthy subjects or between their subgroups. Significant correlations have been detected between expression levels of VDR, CYP27B and SNHG6, SNHG16, Linc00511 and Linc00346 lncRNAs both among COVID-19 patients and among healthy controls with the most significant ones being SNHG6 and SNHG16 (r = 0.74, P value = 3.26e-17 and r = 0.81, P = 1.54e-22, respectively).
Causality:No
Causal Description:
Clinical-realted Application: