Entry Detail

General Information

Database ID: LDA0017598
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:XIST
Full Name:X inactive specific transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):73820651End Site(bp):73852753
External Links:
Ensembl ID:ENSG00000229807
Ensembl Transcript ID:N/A
Entrez Gene:7503.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:84
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Retinoblastoma  (Score: 1)
Retinoblastoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:399D014376
Disease Name:tuberculosisTuberculosis
Category:Disease OntologyMeSH
Type:Infections
Define:A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.
Alias:Tuberculosis//Tuberculoses//Kochs Disease//Koch's Disease//Koch Disease//Mycobacterium tuberculosis Infection//Infection, Mycobacterium tuberculosis//Infections, Mycobacterium tuberculosis//Mycobacterium tuberculosis Infections

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment
Weak Evidence:

 

Reference

[1] PubMed ID:35579934
Disease Name:Tuberculosis
Sample:MTB models
Dysfunction Pattern:Interaction(lncRNA XIST/microRNA-125b-5p/A20/NF-κB axis)
Validated Method:In Vivo Experiment
Description:The MTB models were characterized by upregulated XIST and downregulated miR-125b-5p. XIST bound to miR-125b-5p, leading to its downregulation, and thus causing higher MTB survival in an ESAT-6-dependent manner. Additionally, negative pressure treatment decreased MTB-driven XIST expression through downregulation of A20 (an NF-κB repressor) via miR-125b-5 expression, promoting the M1 polarization program in macrophages through activation of the NF-κB pathway.
Causality:No
Causal Description:
Clinical-realted Application: