Entry Detail

General Information

Database ID: LDA0017600
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:XIST
Full Name:X inactive specific transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66
Chromosome:X
Strand:-
Coordinate:
Start Site(bp):73820651End Site(bp):73852753
External Links:
Ensembl ID:ENSG00000229807
Ensembl Transcript ID:N/A
Entrez Gene:7503.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:84
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Stomach Neoplasms  (Score: 1)
Ovarian Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Retinoblastoma  (Score: 1)
Retinoblastoma  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3393D003324
Disease Name:coronary artery diseaseCoronary Artery Disease
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles.Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Alias:CHD//Coronary disease//coronary arteriosclerosis//coronary heart diseaseCoronary Artery Disease//Artery Disease, Coronary//Artery Diseases, Coronary//Coronary Artery Diseases//Left Main Coronary Artery Disease//Left Main Disease//Left Main Diseases//Left Main Coronary Disease//Coronary Arteriosclerosis//Arterioscleroses, Coronary//Coronary Arterioscleroses//Atherosclerosis, Coronary//Atheroscleroses, Coronary//Coronary Atheroscleroses//Coronary Atherosclerosis//Arteriosclerosis, Coronary

 

Disease Association Statistics

Total Associated ncRNA Number:134   
More Information
Causal ncRNA Number:24
Network:
Top Causal ncRNAs:
MALAT1  (Score: 1)
MALAT1  (Score: 1)
LINC00968  (Score: 0.985791)
LINC00968  (Score: 0.985791)
uc003pxg.1  (Score: 0.731059)
GAS5  (Score: 0.731059)
AGAP2-AS1  (Score: 0.731059)
circLDLR  (Score: 0.731059)
circNPHP4  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qPCR
Weak Evidence:

 

Reference

[1] PubMed ID:32447981
Disease Name:Coronary Artery Disease
Sample:CAD patients
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qPCR
Description:MALAT1 and MIAT were upregulated in CAD patients (p Value= .0008 and .0078, respectively). The expression level of XIST was significantly elevated diabetic compared to non-diabetic CAD patients (p Value= .0003). MALAT1 gene had the highest diagnostic power for discrimination of CAD patients from controls (AUC= 0.682, p Value=.001).
Causality:No
Causal Description:
Clinical-realted Application: