Entry Detail

General Information

Database ID: LDA0017614
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:WFDC21P
Full Name:WAP four-disulfide core domain 21, pseudogene
Category:LncRNA
Species:Homo sapiens
Synonyms:LNCDC|linc-DC|lnc-DC
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):60083566End Site(bp):60088467
External Links:
Ensembl ID:ENSG00000261040
Ensembl Transcript ID:N/A
Entrez Gene:645638.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
lung carcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
lung carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D001528
Disease Name:Behcet Syndrome
Category:MeSH
Type:Stomatognathic Diseases
Define:Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Alias:Behcet Syndrome//Behcet's Syndrome//Triple-Symptom Complex//Triple Symptom Complex//Symptom Complex, Triple//Triple Symptom Complices//Behçet Disease//Behçet Diseases//Adamantiades-Behcet Disease//Adamantiades Behcet Disease//Adamantiades-Behcet Diseases//Behcet Triple Symptom Complex//Old Silk Route Disease//Behcet's Disease//Behcet Disease

 

Disease Association Statistics

Total Associated ncRNA Number:8   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
NONHSAT159216.1  (Score: 0.731059)
NONHSAT159216.1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:35127819
Disease Name:Behcet Syndrome
Sample:BD patients
Dysfunction Pattern:Expression(lower expressed)
Validated Method:qRT-PCR
Description:Compared to controls, the significant upregulation of NEAT1 {median [interquartile range (IQR)] = 1.68 (0.38-7.7), p < 0.0001} and downregulation of lnc-DC [median (IQR) = 0.2 (0.12-1.39), p = 0.03] were detected in the sera collected from BD patients. Also, high NEAT1 levels were significantly associated with a negative pathergy test, while higher lnc-DC was significantly associated with a positive family history
Causality:No
Causal Description:
Clinical-realted Application:Higher serum expression levels of NEAT1 and lnc-DC were significantly associated with the following clinical presentations: cutaneous lesions, vascular manifestations, articular manifestations, neurological manifestations, and higher disease activity score.