Entry Detail

General Information

Database ID: LDA0017663
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ZFAS1
Full Name:ZNFX1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C20orf199|HSUP1|HSUP2|NCRNA00275|ZNFX1-AS1
Chromosome:20
Strand:+
Coordinate:
Start Site(bp):49278178End Site(bp):49289260
External Links:
Ensembl ID:ENSG00000177410
Ensembl Transcript ID:N/A
Entrez Gene:441951.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:86   
More Information
Causal Disease Number:80
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Osteosarcoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Nasopharyngeal carcinoma  (Score: 1)
Uterine Cervical Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:90
Disease Name:degenerative disc disease
Category:Disease Ontology
Type:Nervous System Diseases
Define:A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.
Alias:cervical disc degenerative disease//intervertebral disc degeneration//lumbar disc degeneration//vertebral disc disease

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31876730
Disease Name:degenerative disc disease
Sample:Lumbar disc tissue
Dysfunction Pattern:Expression[Expression[highly expressed]-expression]
Validated Method:qRT-PCR//Western Blot
Description:HNP lncRNA ZFAS1 expression in LDD patients was Expression[Expression[up-expression]-expression]-regulated compared with controls (P < .001)
Causality:No
Causal Description:
Clinical-realted Application:HNP lncRNA ZFAS1 expression in LDD patients was Expression[Expression[up-expression]-expression]-regulated compared with controls (P < .001), and receiver operating characteristic (ROC) curve showed lncRNA ZFAS1 expression disclosed a good predictive value for LDD risk with area under curve (AUC) 0.753 (95% CI 0.646-0.859). And after adjustment by age, gender and body mass index (BMI), lncRNA ZFAS1 (P = .017) remained to be an independent predictive factor for higher LDD risk.