| | Disease Ontology | MeSH |
| Disease ID: | DOID:1470 | D003865 |
| Disease Name: | major depressive disorder | Depressive Disorder, Major |
| Category: | Disease Ontology | MeSH |
| Type: | | Mental Disorders |
| Define: | A depressive disorder that is characterized by at least two weeks of loss of interest or pleasure in normally enjoyable activities or depressed mood along with additional cognitive or somatic impairments such as appetite or weight changes, sleep difficulties, psychomotor agitation or retardation, fatigue or loss of energy, diminished ability to think or concentrate, feelings of worthlessness or excessive guilt, and suicidality. | Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5) |
| Alias: | clinical depression//major depression//recurrent major depression//single major depressive episode//unipolar depression | Depressive Disorder, Major//Depressive Disorders, Major//Major Depressive Disorders//Major Depressive Disorder//Paraphrenia, Involutional//Involutional Paraphrenia//Involutional Paraphrenias//Paraphrenias, Involutional//Psychosis, Involutional//Involutional Psychoses//Involutional Psychosis//Psychoses, Involutional//Depression, Involutional//Involutional Depression//Melancholia, Involutional//Involutional Melancholia |
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