Entry Detail

General Information

Database ID: LDA0017763
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:THRIL
Full Name:TNF and HNRNPL related immunoregulatory long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:BRI3BP-AS1|BRI3BPAS1|Linc1992|TCONS_00020260
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):125025443End Site(bp):125027423
External Links:
Ensembl ID:ENSG00000280634
Ensembl Transcript ID:N/A
Entrez Gene:102659353.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Arthritis, Rheumatoid  (Score: 0.999893)
Arthritis, Rheumatoid  (Score: 0.999893)
Osteosarcoma  (Score: 0.731059)
Coronary Disease  (Score: 0.731059)
Lung Injury  (Score: 0.731059)
Cerebral Ischaemia/Reperfusion Injury  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Coronary Disease  (Score: 0.731059)
Lung Injury  (Score: 0.731059)
Cerebral Ischaemia/Reperfusion Injury  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050589D015212
Disease Name:inflammatory bowel diseaseInflammatory Bowel Diseases
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:An intestinal disease characterized by inflammation located in all parts of digestive tract.Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
Alias:Inflammatory Bowel Diseases//Inflammatory Bowel Disease//Bowel Diseases, Inflammatory

 

Disease Association Statistics

Total Associated ncRNA Number:50   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
CRNDE  (Score: 0.731059)
NEAT1  (Score: 0.731059)
CRNDE  (Score: 0.731059)
NEAT1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:36206229
Disease Name:Inflammatory Bowel Diseases
Sample:UC patients
Dysfunction Pattern:Interaction(MiR-125b)
Validated Method:qRT-PCR
Description:Our results showed a significant increase in the fold change of LncRNA THRIL in UC patients (Median = 11.11, IQR; 10.21-12.45, P<0.001) and CD patients (Median = 5.87, IQR; 4.57-7.88, P<0.001) compared to controls. Furthermore, there was a negative significant correlation between LncRNA THRIL and MiR-125b in UC patients (r = -0.28, P = 0.016) and in CD patients (r = -0.772, P<0.001). ROC curve analysis was done showing the diagnostic value of these markers as predictors in differentiating between cases of UC, CD, and control.
Causality:No
Causal Description:
Clinical-realted Application: