Entry Detail

General Information

Database ID: LDA0017764
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:THRIL
Full Name:TNF and HNRNPL related immunoregulatory long non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:BRI3BP-AS1|BRI3BPAS1|Linc1992|TCONS_00020260
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):125025443End Site(bp):125027423
External Links:
Ensembl ID:ENSG00000280634
Ensembl Transcript ID:N/A
Entrez Gene:102659353.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:22   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Arthritis, Rheumatoid  (Score: 0.999893)
Arthritis, Rheumatoid  (Score: 0.999893)
Osteosarcoma  (Score: 0.731059)
Coronary Disease  (Score: 0.731059)
Lung Injury  (Score: 0.731059)
Cerebral Ischaemia/Reperfusion Injury  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Coronary Disease  (Score: 0.731059)
Lung Injury  (Score: 0.731059)
Cerebral Ischaemia/Reperfusion Injury  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D012128
Disease Name:Respiratory Distress Syndrome
Category:MeSH
Type:Respiratory Tract Diseases
Define:A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA.
Alias:Respiratory Distress Syndrome//Distress Syndrome, Respiratory//Distress Syndromes, Respiratory//Respiratory Distress Syndromes//Syndrome, Respiratory Distress//Shock Lung//Lung, Shock//Respiratory Distress Syndrome, Acute//Acute Respiratory Distress Syndrome//ARDS, Human//Human ARDS//Respiratory Distress Syndrome, Pediatric//Pediatric Respiratory Distress Syndrome//Respiratory Distress Syndrome, Adult//Adult Respiratory Distress Syndrome

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
SNHG5  (Score: 0.731059)
H19  (Score: 0.731059)
SNHG5  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31257645
Disease Name:Respiratory Distress Syndrome
Sample:blood
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:Lnc-THRIL was upregulated in ARDS group compared with non-ARDS group, and it had good value in distinguishing ARDS from non-ARDS in sepsis patients (AUC: 0.706; 95%CI: 0.602-0.809).
Causality:No
Causal Description:
Clinical-realted Application:THRIL positively correlated with APACHE II score and SOFA score in sepsis patients. Regarding inflammation, lnc-THRIL was positively associated with CRP, PCT, TNF-α, and IL-1β levels in sepsis patients. Additionally, the mortality rate was 30.2%, and lnc-THRIL was upregulated in non-survivors compared with survivors, presenting a good value (AUC: 0.780; 95%CI: 0.683-0.876) in predicting mortality in sepsis patients.