Entry Detail

General Information

Database ID: LDA0017808
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TINCR
Full Name:TINCR ubiquitin domain containing
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00036|NCRNA00036|PLAC2|TUBL|onco-lncRNA-16
Chromosome:19
Strand:-
Coordinate:
Start Site(bp):5558167End Site(bp):5567953
External Links:
Ensembl ID:ENSG00000223573
Ensembl Transcript ID:N/A
Entrez Gene:257000.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:32
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Breast Neoplasms  (Score: 0.985791)
Melanoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Melanoma  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11946D000026
Disease Name:obsolete habitual abortionAbortion, Habitual
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:Three or more consecutive spontaneous abortions.
Alias:Aborter - recurrent//Habitual aborter//Habitual aborter - unspecified (disorder)//Habitual aborter NOS (disorder)//chronic spontaneous abortion//recurrent abortion (disorder)//recurrent miscarriageAbortion, Habitual//Habitual Abortion//Habitual Abortions//Abortion, Recurrent//Recurrent Abortion//Recurrent Abortions//Miscarriage, Recurrent//Recurrent Miscarriage//Recurrent Miscarriages//Recurrent Early Pregnancy Loss

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
lnc-CES1-1  (Score: 0.731059)
lnc-CES1-1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:31124188
Disease Name:Abortion, Habitual
Sample:blood
Dysfunction Pattern:Mutation[rs2288947 ]
Validated Method:Genotyping
Description:Therefore, we investigated the relationship between the rs2288947 A > G polymorphism of the lncRNA TINCR and susceptibility to recurrent abortion. We recruited 248 recurrent spontaneous abortion patients and 392 healthy control subjects from the Southern Chinese population and used the TaqMan method for genotyping. There was no evidence that this polymorphism is associated with recurrent miscarriage (AG vs AA: adjusted OR = 0.904, 95% CI = 0.647-1.264, P = 0.5552; GG and AA: adjusted OR = 0.871, 95% CI = 0.475-1.597, P = 0.6542; dominant model: AG/GG vs AA: adjusted OR = 0.898, 95% CI = 0.653-1.236, P = 0.5101; and recessive model: GG vs AA/AG: adjusted OR = 0.910, 95% CI = 0.505-1.639, P = 0.7527). The stratified analysis also showed no significant associations. This study suggests that the rs2288947 A > G polymorphism of the lncRNA TINCR may not be associated with recurrent miscarriage in a Southern Chinese population.
Causality:No
Causal Description:
Clinical-realted Application: