Entry Detail

General Information

Database ID: LDA0017894
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TUG1
Full Name:taurine up-regulated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00080|NCRNA00080|TI-227H
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):30969265End Site(bp):30979395
External Links:
Ensembl ID:ENSG00000253352
Ensembl Transcript ID:N/A
Entrez Gene:55000.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:106   
More Information
Causal Disease Number:66
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 0.999998)
Leukemia, Myeloid, Acute  (Score: 0.999998)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9778D043183
Disease Name:irritable bowel syndromeIrritable Bowel Syndrome
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:An intestinal disease that is characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.A disorder with chronic or recurrent colonic symptoms without a clearcut etiology. This condition is characterized by chronic or recurrent ABDOMINAL PAIN, bloating, MUCUS in FECES, and an erratic disturbance of DEFECATION.
Alias:IBD//Irritable colonIrritable Bowel Syndrome//Irritable Bowel Syndromes//Syndrome, Irritable Bowel//Syndromes, Irritable Bowel//Colon, Irritable//Irritable Colon//Colitis, Mucous//Colitides, Mucous//Mucous Colitides//Mucous Colitis

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:36428545
Disease Name:Irritable Bowel Syndrome
Sample:42 diabetic patients, 42 diabetic patients with IBS, and 42 healthy controls
Dysfunction Pattern:Expression(lower expressed)
Validated Method:qRT-PCR
Description:H19 and TUG1 were downregulated in patients with poor glycemic control. Diabetic patients with IBS had significantly lower levels of lncRNA H19 and TUG1 expression than healthy controls and diabetic-only patients.
Causality:No
Causal Description:
Clinical-realted Application:H19 and TUG1 were downregulated in patients with poor glycemic control. lncRNA H19 and TUG1 expression in diabetic patients with IBS significantly negatively correlated with the IBS severity scoring system. Both lncRNAs’ expression significantly predicted the disease severity.