Entry Detail

General Information

Database ID: LDA0017914
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:TUG1
Full Name:taurine up-regulated 1
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00080|NCRNA00080|TI-227H
Chromosome:22
Strand:+
Coordinate:
Start Site(bp):30969265End Site(bp):30979395
External Links:
Ensembl ID:ENSG00000253352
Ensembl Transcript ID:N/A
Entrez Gene:55000.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:106   
More Information
Causal Disease Number:66
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Osteosarcoma  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Leukemia, Myeloid, Acute  (Score: 0.999998)
Leukemia, Myeloid, Acute  (Score: 0.999998)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8398D010003
Disease Name:osteoarthritisOsteoarthritis
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that has_material_basis_in worn out cartilage located_in joint.A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Alias:Osteoarthrosis and allied disorder//degenerative arthritis//degenerative joint disease//hypertrophic arthritis//osteoarthrosisOsteoarthritis//Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans

 

Disease Association Statistics

Total Associated ncRNA Number:784   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
MCM3AP-AS1  (Score: 0.985791)
hsa_circ_0005567  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
XIST  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30575896
Disease Name:Osteoarthritis
Sample:cartilages of patients with osteoarthritis
Dysfunction Pattern:Regulation[miR-195/MMP-13 axis]
Validated Method:qRT-PCR
Description:The expression levels of lncRNA-TUG1 and MMP-13 in cartilages of patients with osteoarthritis were higher than those in cartilages of normal people, while the level of miR-195 decreased in cartilages of patients with osteoarthritis. LncRNA-TUG1 regulates the degradation of extracellular matrix in osteoarthritis via lncRNA-TUG1/miR-195/MMP-13 axis.
Causality:No
Causal Description:
Clinical-realted Application: