Entry Detail

General Information

Database ID: LDA0017995
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PM20D1-AS1
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:N/A
NONCODE ID:N/A
RefSeq Accession:NR_046098.1

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:437D009157
Disease Name:myasthenia gravisMyasthenia Gravis
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath.A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.
Alias:Myasthenia Gravis//Myasthenia Gravis, Ocular//Ocular Myasthenia Gravis//Myasthenia Gravis, Generalized//Generalized Myasthenia Gravis//Muscle-Specific Receptor Tyrosine Kinase Myasthenia Gravis//Muscle Specific Receptor Tyrosine Kinase Myasthenia Gravis//Muscle-Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis//Muscle Specific Tyrosine Kinase Antibody Positive Myasthenia Gravis//MuSK MG//MuSK Myasthenia Gravis//Myasthenia Gravis, MuSK//Anti-MuSK Myasthenia Gravis//Anti MuSK Myasthenia Gravis//Myasthenia Gravis, Anti-MuSK

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
LINC00680  (Score: 0.731059)
circFBL  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
LINC00680  (Score: 0.731059)
circFBL  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:33543801
Disease Name:Myasthenia Gravis
Sample:
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR//RNA-seq
Description:We identified 378 significantly upregulated and 348 significantly downregulated lncRNAs in MG patients compared with HC. The top 5 lncRNAs (NR_104677.1, ENST00000583253.1, NR_046098.1, NR_022008.1, and ENST00000581362.1) were validated and shown to be significantly increased in the serum exosome of MG, and the expression level of NR_046098.1 significantly increased with the MG grading.
Causality:No
Causal Description:
Clinical-realted Application: