Entry Detail


General Information

Database ID: LDA0017999
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PLUT
Full Name:PDX1 associated lncRNA, upregulator of transcription
Category:LncRNA
Species:Homo sapiens
Synonyms:HI-LNC71|PDX1-AS1|PLUTO
Chromosome:13
Strand:-
Coordinate:
Start Site(bp):27819092End Site(bp):27917291
External Links:
Ensembl ID:ENSG00000247381
Ensembl Transcript ID:N/A
Entrez Gene:100861550.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9351D003920
Disease Name:diabetes mellitusDiabetes Mellitus
Category:Disease OntologyMeSH
Type:Nutritional and Metabolic Diseases
Define:A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Alias:Diabetes Mellitus

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
HAND2-AS1  (Score: 0.731059)
LINC-PINT  (Score: 0.731059)
AQP4-AS1  (Score: 0.731059)
PRINS  (Score: 0.731059)
TINCR  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
LINC-PINT  (Score: 0.731059)
AQP4-AS1  (Score: 0.731059)
PRINS  (Score: 0.731059)
TINCR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30139387
Disease Name:Diabetes Mellitus
Sample:peripheral blood mononuclear cells
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:Compared to control subjects, expression levels of lncRNAs in PBMCs from type 2 diabetes patients showed significantly (p < 0.05) increased levels of HOTAIR, MEG3, LET, MALAT1, MIAT, CDKN2BAS1/ANRIL, XIST, PANDA, GAS5, Linc-p21, ENST00000550337.1, PLUTO, and NBR2. In contrast, lncRNA expression patterns of THRIL and SALRNA1 were significantly (p < 0.05) decreased in patients with T2DM compared to control subjects.
Causality:No
Causal Description:
Clinical-realted Application: