Entry Detail

General Information

Database ID: LDA0018118
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:RAMP2-AS1
Full Name:RAMP2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):42753914End Site(bp):42761257
External Links:
Ensembl ID:ENSG00000197291
Ensembl Transcript ID:N/A
Entrez Gene:100190938.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:0
Network:
Top Causal Diseases:
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3371D002813
Disease Name:chondrosarcomaChondrosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage.A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)
Alias:Cartilaginous cancer//chondrosarcoma of bone//primary chondrosarcoma of the boneChondrosarcoma//Chondrosarcomas

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
SNHG6  (Score: 0.731059)
SNHG6  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32368088
Disease Name:Chondrosarcoma
Sample:serum
Dysfunction Pattern:regulation[miR-2355-5p/VEGFR2 Axis]
Validated Method:qRT-PCR//Transwell Assay
Description:LncRNA microarray analysis revealed that exosomes carried lncRNA RAMP2-AS1, and further verification showed that the level of RAMP2-AS1 was increased in the serum of chondrosarcoma patients and was closely related to local invasiveness, distant metastasis and poor prognosis. Moreover, dual luciferase reporter assay and rescue experiments suggested that the RAMP2-AS1/miR-2355-5p/VEGFR2 axis was responsible for exosome-induced angiogenesis of HUVECs.
Causality:No
Causal Description:
Clinical-realted Application:LncRNA microarray analysis revealed that exosomes carried lncRNA RAMP2-AS1, and further verification showed that the level of RAMP2-AS1 was increased in the serum of chondrosarcoma patients and was closely related to local invasiveness, distant metastasis and poor prognosis.