Entry Detail

General Information

Database ID: LDA0018165
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PTCSC3
Full Name:papillary thyroid carcinoma susceptibility candidate 3
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:14
Strand:-
Coordinate:
Start Site(bp):36135710End Site(bp):36176651
External Links:
Ensembl ID:ENSG00000259104
Ensembl Transcript ID:N/A
Entrez Gene:100886964.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Mouth Neoplasms  (Score: 0.731059)
Osteoporosis  (Score: 0.731059)
oral cavity cancer  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:824D010518
Disease Name:periodontitisPeriodontitis
Category:Disease OntologyMeSH
Type:Stomatognathic Diseases
Define:Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Alias:chronic pericementitisPeriodontitis//Periodontitides//Pericementitis//Pericementitides

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
hsa_circ_0138959  (Score: 0.731059)
hsa_circ_0099630  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
Nron  (Score: 0.731059)
hsa_circ_0138959  (Score: 0.731059)
hsa_circ_0099630  (Score: 0.731059)
OIP5-AS1  (Score: 0.731059)
Nron  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31196168
Disease Name:Periodontitis
Sample:periodontal ligament stem cells
Dysfunction Pattern:Interaction[TLR4 ]
Validated Method:qRT-PCR//Western Blot
Description:In this study we found that PTCSC3 was downregulated, while toll-like receptor 4 (TLR4) was upregulated in periodontal ligament stem cells (PDLSCs) isolated from periodontitis affected teeth that in PDLSCs isolated from healthy teeth. Therefore, lncRNA PTCSC3 may regulate the proliferation of PDLSCs and TLR4 expression to improve periodontitis.
Causality:No
Causal Description:
Clinical-realted Application: