Entry Detail

General Information

Database ID: LDA0018193
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PVT1
Full Name:Pvt1 oncogene
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00079|MIR1204HG|NCRNA00079|TP53LC09|onco-lncRNA-100
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127794533End Site(bp):128101253
External Links:
Ensembl ID:ENSG00000249859
Ensembl Transcript ID:N/A
Entrez Gene:5820.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:128   
More Information
Causal Disease Number:100
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Prostatic Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Renal Cell  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:784D051436
Disease Name:chronic kidney diseaseRenal Insufficiency, Chronic
Category:Disease OntologyMeSH
Type:Urogenital Diseases
Define:A kidney failure that is characterized by the gradual loss of kidney function.Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
Alias:CKD//CRF//chronic kidney failure//chronic renal disease//chronic renal failure syndrome//renal failure - chronicRenal Insufficiency, Chronic//Chronic Renal Insufficiencies//Renal Insufficiencies, Chronic//Chronic Renal Insufficiency//Kidney Insufficiency, Chronic//Chronic Kidney Insufficiency//Chronic Kidney Insufficiencies//Kidney Insufficiencies, Chronic//Chronic Kidney Diseases//Chronic Kidney Disease//Disease, Chronic Kidney//Diseases, Chronic Kidney//Kidney Disease, Chronic//Kidney Diseases, Chronic//Chronic Renal Diseases//Chronic Renal Disease//Disease, Chronic Renal//Diseases, Chronic Renal//Renal Disease, Chronic//Renal Diseases, Chronic

 

Disease Association Statistics

Total Associated ncRNA Number:10   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
H19  (Score: 0.731059)
CDKN2B-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:34563213
Disease Name:Renal Insufficiency, Chronic
Sample:CHF patients
Dysfunction Pattern:Expression(lower expressed)
Validated Method:qRT-PCR
Description:Plasma PVT1 was downregulated in CHF and further downregulated in CHF patients complicated with progressive CKD.
Causality:No
Causal Description:
Clinical-realted Application: ROC curve analysis showed that plasma PVT1 levels could be used to distinguish CHF patients complicated with CKD from CHF patients without CKD and healthy controls. During a 2-year follow-up, patients with high CHF levels had a low incidence of progressive CKD among CHF patients. Moreover, with the treatment of progressive CKD, plasma PVT1 was upregulated.