Entry Detail

General Information

Database ID: LDA0018336
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:OTUD6B-AS1
Full Name:OTUD6B antisense RNA 1 (head to head)
Category:LncRNA
Species:Homo sapiens
Synonyms:GS1-251I9.4
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):91059906End Site(bp):91070189
External Links:
Ensembl ID:ENSG00000253738
Ensembl Transcript ID:N/A
Entrez Gene:100506365.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:418D012595
Disease Name:systemic sclerodermaScleroderma, Systemic
Category:Disease OntologyMeSH
Type:Skin and Connective Tissue Diseases
Define:A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Alias:Scleroderma//Scleroderma syndrome//progressive systemic sclerosis//systemic sclerosisScleroderma, Systemic//Systemic Sclerosis//Sclerosis, Systemic//Systemic Scleroderma

 

Disease Association Statistics

Total Associated ncRNA Number:6   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:BrdU//ELISA//qPCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31156645
Disease Name:Scleroderma, Systemic
Sample:SSc skin biopsies
Dysfunction Pattern:Expression[lower expressed]
Validated Method:BrdU//ELISA//qPCR//Western Blot
Description:Our recent screening experiments by RNA sequencing showed that ovarian tumor domain containing 6B antisense RNA1 (OTUD6B-AS1) and its sense gene OTUD6B were significantly downregulated in SSc skin biopsies.
Causality:No
Causal Description:
Clinical-realted Application: