Entry Detail

General Information

Database ID: LDA0018360
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:PCA3
Full Name:prostate cancer associated 3
Category:LncRNA
Species:Homo sapiens
Synonyms:DD3|NCRNA00019|PCAT3|PRUNE2-AS1
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):76764436End Site(bp):76787569
External Links:
Ensembl ID:ENSG00000225937
Ensembl Transcript ID:N/A
Entrez Gene:50652.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Choriocarcinoma  (Score: 0.731059)
Atherosclerosis  (Score: 0.731059)
Choriocarcinoma  (Score: 0.731059)
Atherosclerosis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0080522D065646
Disease Name:thyroid gland anaplastic carcinomaThyroid Carcinoma, Anaplastic
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thyroid gland carcinoma that is composed of undifferentiated cells.An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.
Alias:anaplastic thyroid carcinomaThyroid Carcinoma, Anaplastic//Anaplastic Thyroid Carcinoma//Anaplastic Thyroid Carcinomas//Carcinoma, Anaplastic Thyroid//Carcinomas, Anaplastic Thyroid//Thyroid Carcinomas, Anaplastic//Thyroid Cancer, Anaplastic//Anaplastic Thyroid Cancer//Anaplastic Thyroid Cancers//Cancer, Anaplastic Thyroid//Cancers, Anaplastic Thyroid//Thyroid Cancers, Anaplastic

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.985791)
UCA1  (Score: 0.985791)
HOTAIRM1  (Score: 0.731059)
HCP5  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP-AS1  (Score: 0.731059)
MANCR  (Score: 0.731059)
HOTAIRM1  (Score: 0.731059)
HCP5  (Score: 0.731059)
H19  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31468286
Disease Name:Thyroid Carcinoma, Anaplastic
Sample:Anaplastic Thyroid Carcinomas tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//Microarray
Description:Two of the upregulated lncRNAs, PCA3 and HAM-1, were analyzed on a thyroid carcinoma TMA. There was increased expression of both lncRNAs in ATCs and PTCs compared with NT after TMA analysis. qRT-PCR analyses showed increased expression of both lncRNAs in ATCs compared with NT and PTCs
Causality:No
Causal Description:
Clinical-realted Application: