Entry Detail

General Information

Database ID: LDA0018426
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:NRON
Full Name:non-coding repressor of NFAT
Category:LncRNA
Species:Homo sapiens
Synonyms:NCRNA00194
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):126407775End Site(bp):126410504
External Links:
Ensembl ID:ENSG00000253079
Ensembl Transcript ID:N/A
Entrez Gene:641373.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Triple Negative Breast Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:12894D012859
Disease Name:Sjogren's syndromeSjogren's Syndrome
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva.Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
Alias:Sicca syndrome//Sjogren syndrome//xerodermosteosisSjogren's Syndrome//Sjogrens Syndrome//Syndrome, Sjogren's//Sjogren Syndrome//Sicca Syndrome//Syndrome, Sicca

 

Disease Association Statistics

Total Associated ncRNA Number:62   
More Information
Causal ncRNA Number:0
Network:
Top Causal ncRNAs:
More Information

 

Evidence Support

Strong Evidence:ISH//IHC//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34261974
Disease Name:Sjogren's Syndrome
Sample:LSGs
Dysfunction Pattern:Interaction(NFATc1/PIM-1)
Validated Method:ISH//IHC//IF
Description:The NRON expression in the nuclei of cell-infiltration lesions of the SS patients were prominent. The NFATc1 expression was strong in the cytoplasm of infiltrating mononuclear cells and weak in ducts of both SS and controls. In SS, the NFATc1-positive area/infiltrating cell area was positively correlated with the infiltrating cell area and focus score. CD3/CD4 was expressed in infiltrating mononuclear cells, and PIM-1 colocalized with NFATc1 in the cytoplasm. These results suggest NRON along with NFATc1/PIM-1 in SS LSGs might participate in SS pathophysiology.
Causality:No
Causal Description:
Clinical-realted Application: