Entry Detail

General Information

Database ID: LDA0018533
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Unknown
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:SENCR
Full Name:smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA
Category:LncRNA
Species:Homo sapiens
Synonyms:FLI1-AS1|lncRNA9
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):128691672End Site(bp):128696023
External Links:
Ensembl ID:ENSG00000254703
Ensembl Transcript ID:N/A
Entrez Gene:100507392.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Aortic Aneurysm, Abdominal  (Score: 0.731059)
Coronary Disease  (Score: 0.731059)
Aortic Aneurysm, Abdominal  (Score: 0.731059)
Coronary Disease  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3369D012512
Disease Name:Ewing sarcomaSarcoma, Ewing
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A connective tissue cancer that has_material_basis_in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm.A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females.
Alias:Ewing's family localized tumor//Ewing's sarcoma/peripheral primitive neuroectodermal tumor//Ewing's tumor//Ewings sarcoma//Ewings sarcoma-primitive neuroectodermal tumor//PNET of Thoracopulmonary Region//localized Ewing sarcoma//localized Ewing's sarcoma//localized Ewing's sarcoma/peripheral primitive neuroectodermal tumor//localized Ewing's tumor//localized peripheral primitive neuroectodermal tumor//peripheral primitive neuroectodermal tumorSarcoma, Ewing//Sarcoma, Ewing's//Sarcoma, Ewings//Ewing's Sarcoma//Ewings Sarcoma//Ewing's Tumor//Ewings Tumor//Tumor, Ewing's//Ewing Sarcoma//Ewing Tumor//Tumor, Ewing

 

Disease Association Statistics

Total Associated ncRNA Number:8   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
FOXP4-AS1  (Score: 0.731059)
TUG1  (Score: 0.731059)
FOXP4-AS1  (Score: 0.731059)
TUG1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Genotyping
Weak Evidence:

 

Reference

[1] PubMed ID:36338681
Disease Name:Sarcoma, Ewing
Sample:populations
Dysfunction Pattern:Mutation(rs10893909, rs11221437, rs12420823, rs4526784)
Validated Method:Genotyping
Description: An association between polymorphisms and EWS susceptibility was observed for three IGF2BP3 SNPs - rs112316332, rs13242065, rs12700421 - and for four SENCR SNPs - rs10893909, rs11221437, rs12420823, rs4526784 -. In addition, IGF2BP3 rs34033684 and SENCR rs10893909 variants increased the risk for female respect to male subgroup when carried together, while IGF2BP3 rs13242065 or rs76983703 variants reduced the probability of a disease later onset (> 14 years). Moreover, the absence of IGF2BP3 rs10488282 variant and the presence of rs199653 or rs35875486 variant were significantly associated with a worse survival in EWS patients with localized disease at diagnosis.
Causality:No
Causal Description:
Clinical-realted Application: